Zebrafish Igf2a Antibody / Igf2 / Insulin-like growth factor 2 (RZ1199)

Description

Insulin-like growth factor 2a (Igf2a) is one of two zebrafish paralogs of the mammalian IGF2, a growth factor involved in regulating cell proliferation, differentiation, metabolism, and survival. In zebrafish (Danio rerio), Igf2a plays a key role in embryonic growth, organ development, and tissue regeneration, acting through the IGF signaling axis that is conserved across vertebrates.

Igf2a functions by binding to the insulin-like growth factor 1 receptor (IGF1R), activating downstream signaling pathways such as PI3K-Akt and MAPK/ERK, which promote anabolic processes and inhibit apoptosis. In zebrafish, igf2a is expressed during early development and in growing tissues such as the heart, liver, and muscle, and has been shown to influence myogenesis, neurogenesis, and organ size regulation.

Due to its importance in growth and regenerative pathways, zebrafish Igf2a is widely used as a model for studying developmental biology, metabolic regulation, and growth-related disorders. It is also of interest in research on wound healing, cardiac regeneration, and tumor biology.

Application Notes

Optimal dilution of the Zebrafish Igf2a antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Igf2a recombinant protein (amino acids G41-K197) was used as the immunogen for the Zebrafish Igf2a antibody.

Storage

After reconstitution, the Zebrafish Igf2a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.