SHP2 Antibody / PTPN11 [clone GBO-16] (RQ8892)

Description

SHP2 (PTPN11) is a cytoplasmic protein tyrosine phosphatase that plays a central role in multiple signaling pathways, including the RAS/MAPK cascade. It contains two SH2 domains that mediate interactions with phosphorylated proteins and a catalytic domain responsible for its phosphatase activity, regulating cell growth, differentiation, and migration.

SHP2 is essential for normal embryonic development, immune regulation, and tissue homeostasis. Mutations in SHP2 are associated with disorders such as Noonan syndrome, LEOPARD syndrome, and various cancers. Research on SHP2 provides valuable insights into the molecular mechanisms of signaling and their roles in both health and disease.

Using a high-quality SHP2 antibody enables precise detection in applications including western blot, immunohistochemistry, and immunoprecipitation. An SHP2 antibody from NSJ Bioreagents offers consistent performance for studies on cell signaling, developmental biology, and oncogenesis. Selecting the right SHP2 antibody ensures accurate and reproducible research outcomes.

Application Notes

Optimal dilution of the SHP2 antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to SHP2 was used as the immunogen for the SHP2 antibody.

Storage

After reconstitution, the SHP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.