RBP4 Antibody / Retinol Binding Protein 4 (R31773)

Description

RBP4 (Retinol Binding Protein 4) is a secreted transport protein primarily responsible for delivering retinol (vitamin A alcohol) from the liver to peripheral tissues. Synthesized mainly by hepatocytes and adipocytes, RBP4 binds retinol in a 1:1 molar ratio and forms a complex with transthyretin in the bloodstream to prevent renal filtration. This transport mechanism is essential for maintaining retinoid homeostasis, which is critical for vision, cellular differentiation, immune function, and embryonic development.

Beyond its classical role in vitamin A metabolism, RBP4 has been identified as a key player in metabolic regulation. Elevated serum levels of RBP4 are associated with insulin resistance, obesity, type 2 diabetes, and cardiovascular disease. Consequently, RBP4 is increasingly recognized as both a biomarker and a potential therapeutic target in metabolic syndrome and related disorders.

The RBP4 antibody is a valuable tool for detecting RBP4 expression and distribution in various tissues and biological samples. Commonly used in western blot, ELISA, and immunohistochemistry applications, the RBP4 antibody provides high specificity and sensitivity for studying retinoid transport and metabolic regulation. Whether investigating liver function, adipose biology, or metabolic disease, the RBP4 antibody offers reliable performance for both basic and translational research.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the RBP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Human partial recombinant protein (AA 19-201) was used as the immunogen for this RBP4 antibody.

Storage

After reconstitution, the RBP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.