RAB11A Antibody (R31406)

Description

RAB11A (Ras-related protein Rab-11A) is a small GTP-binding protein that belongs to the Rab family, which regulates intracellular membrane trafficking. RAB11 is primarily associated with the recycling endosome, where it controls the recycling of proteins and lipids back to the plasma membrane. This function is essential for processes such as receptor trafficking, cytokinesis, and maintenance of cell polarity. A RAB11A antibody is widely used to study endosomal transport and recycling pathways.

As a molecular switch, RAB11A cycles between an active GTP-bound form and an inactive GDP-bound form. In its active state, it recruits effector proteins that mediate vesicle budding, movement, and fusion. By regulating transport of receptors such as transferrin and integrins, RAB11A plays a vital role in nutrient uptake, adhesion, and signal transduction. Researchers employ a RAB11A antibody to explore these trafficking processes and their contributions to cell physiology.

RAB11A has also been implicated in diverse biological processes beyond vesicle trafficking. It influences epithelial morphogenesis, ciliogenesis, and immune responses by directing membrane flow to specific subcellular locations. Dysregulation of RAB11A function has been linked to cancer progression, infectious disease, and neurological disorders, where altered endosomal trafficking disrupts signaling and cell homeostasis. Using a RAB11A antibody allows for precise detection of its expression and localization in these research contexts.

NSJ Bioreagents provides a high-quality RAB11A antibody validated for applications such as western blot, immunohistochemistry, and immunofluorescence. Choosing a validated RAB11A antibody from NSJ Bioreagents ensures reproducibility and accuracy in studies of membrane trafficking, recycling endosomes, and disease mechanisms.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the RAB11A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the C-terminus of human RAB11A (NVVPIHVPPTTENKPKVQ) was used as the immunogen for this RAB11A antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the RAB11A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.