PDC-E2 Antibody / Pyruvate Dehydrogenase E2 [clone 23D09] (RQ8897)

Description

Pyruvate dehydrogenase E2 (PDC-E2) is the dihydrolipoamide acetyltransferase component of the pyruvate dehydrogenase complex, a key mitochondrial enzyme complex linking glycolysis to the citric acid cycle. PDC-E2 catalyzes the transfer of an acetyl group from pyruvate to coenzyme A, producing acetyl-CoA for cellular energy metabolism.

PDC-E2 is essential for efficient carbohydrate oxidation and energy production. It is also the primary autoantigen recognized in primary biliary cholangitis (PBC), an autoimmune liver disease, making it important in both metabolic and immunological research.

Using a high-quality PDC-E2 antibody enables accurate detection in applications such as western blot, immunohistochemistry, and ELISA. A PDC-E2 antibody from NSJ Bioreagents ensures sensitivity and reproducibility for studies involving mitochondrial function, metabolic pathways, and autoimmune disease. Selecting the right PDC-E2 antibody is critical for producing consistent and reliable research results.

Application Notes

Optimal dilution of the PDC-E2 antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to Pyruvate Dehydrogenase E2 was used as the immunogen for the PDC-E2 antibody.

Storage

After reconstitution, the PDC-E2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.