ERGIC1 Antibody / ERGIC-32 (RQ7397)

Description

Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) is a membrane-associated protein that plays a key role in protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. ERGIC1 is a component of the ER-Golgi intermediate compartment, a central hub for cargo sorting and vesicle formation during early secretory pathway processes. Its function is critical for maintaining proper cellular homeostasis and protein secretion.

ERGIC1 is conserved across species and the human ERGIC1 gene encodes a protein of approximately 33 kDa. Multiple isoforms of ERGIC1 have been reported, arising from alternative splicing events, which may influence subcellular localization or trafficking efficiency. These isoforms can have distinct regulatory roles in vesicular transport, making them important in studies of protein processing and intracellular transport.

The ERGIC1 antibody is a valuable tool for investigating the dynamics of the early secretory pathway and ER-Golgi trafficking. Researchers use an ERGIC1 antibody in various applications such as western blotting, immunofluorescence, and immunohistochemistry to detect ERGIC1 expression patterns in different tissues or experimental conditions. The ERGIC1 antibody enables precise detection of both native and isoform-specific forms of the protein, aiding studies in cell biology, molecular trafficking, and secretory pathway disorders.

Application Notes

Optimal dilution of the ERGIC1 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids S42-H290) was used as the immunogen for the ERGIC1 antibody.

Storage

After reconstitution, the ERGIC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.