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Home >> Antibodies >> Cofilin 2 Antibody / CFL2

Cofilin 2 Antibody / CFL2 [clone CFL2/9963] (V5657)

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  Catalog No Formulation Size Price (USD)  
Image V5657-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5657-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5657SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human skeletal muscle tissue with Cofilin 2 antibody (clone CFL2/9963). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human skeletal muscle tissue with Cofilin 2 antibody (clone CFL2/9963). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Cofilin 2 antibody (clone CFL2/9963) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name CFL2/9963
Purity Protein G affinity
UniProt Q9Y281
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This Cofilin 2 antibody is available for research use only.
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Description

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Application Notes

Optimal dilution of the Cofilin 2 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-166 from human CFL2 protein was used as the immunogen for the Cofilin 2 antibody.

Storage

Aliquot the Cofilin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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