CD247 Antibody / CD3 zeta [clone IHI-3] (RQ8903)

Description

CD247 (CD3 zeta) is a key signaling component of the T cell receptor (TCR) complex, essential for antigen recognition and T cell activation. It contains multiple immunoreceptor tyrosine-based activation motifs (ITAMs) that initiate downstream signaling cascades upon antigen engagement, leading to T cell proliferation and differentiation.

CD247 is predominantly expressed in T cells and natural killer (NK) cells, where it regulates immune responses against pathogens and abnormal cells. Alterations in CD247 expression or function have been linked to immunodeficiencies, autoimmune diseases, and cancer, making it a valuable focus for immunological research.

Using a high-quality CD247 antibody enables precise detection in applications such as western blot, flow cytometry, and immunohistochemistry. A CD247 antibody from NSJ Bioreagents ensures reproducibility and sensitivity for studies in T cell biology, immune signaling, and disease pathogenesis. Selecting the right CD247 antibody is essential for producing accurate and consistent research results.

Application Notes

Optimal dilution of the CD247 antibody should be determined by the researcher.

Immunogen

A peptide sequence specific to CD3 zeta protein was used as the immunogen for the CD247 antibody.

Storage

After reconstitution, the CD247 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.