Zebrafish Star Antibody / Steroidogenic acute regulatory protein (RZ1317)

Description

Zebrafish Star, also known as steroidogenic acute regulatory protein, is a key mitochondrial protein involved in the transport of cholesterol from the outer to the inner mitochondrial membrane. This transport step is essential for the initiation of steroid hormone biosynthesis. By facilitating cholesterol delivery to the cytochrome P450 enzyme system, Star regulates the production of hormones such as cortisol, estrogen, and testosterone. In zebrafish, Star is crucial for the development and function of steroidogenic tissues, including the gonads and interrenal gland.

Zebrafish Star is an ortholog of the human STAR protein, with strong sequence and functional conservation across vertebrates. As in humans, zebrafish Star plays a vital role in maintaining proper hormone synthesis and reproductive health. Disruption of Star function can lead to impaired steroidogenesis and developmental abnormalities, making it an important focus for research on endocrine system regulation.

The use of a Zebrafish Star antibody allows scientists to study the expression and localization of Star in various tissues during development and under experimental conditions. Such antibodies are valuable for applications like western blot, immunohistochemistry, and immunofluorescence, providing insights into how Star activity influences hormone production. A Zebrafish Star antibody is also useful for investigating the effects of environmental stressors or chemical modulators on steroid biosynthesis.

There are no reported isoforms of zebrafish Star. Due to the high degree of conservation between zebrafish Star and its human counterpart, findings obtained with a Zebrafish Star antibody can be applied to understanding steroidogenesis in human health and disease.

Application Notes

Optimal dilution of the Zebrafish Star antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Star recombinant protein (amino acids A62-C285) was used as the immunogen for the Zebrafish Star antibody.

Storage

After reconstitution, the Zebrafish Star antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.