Zebrafish Sox3 Antibody / SRY-box 3 (RZ1194)

Description

SRY-box transcription factor 3 (Sox3) is a member of the SoxB1 subfamily of transcription factors, which are key regulators of early embryonic development and neural differentiation. In zebrafish (Danio rerio), Sox3 plays a critical role in the formation of the nervous system, maintenance of neural progenitor identity, and early ectodermal patterning.

Sox3 is maternally deposited and is expressed in the neuroectoderm during early development. It acts as a transcriptional activator that promotes neural fate by regulating genes involved in progenitor cell maintenance and inhibiting premature neuronal differentiation. Sox3 also contributes to the development of the pituitary gland, sensory placodes, and hypothalamic structures.

Due to its conservation across vertebrates, zebrafish Sox3 serves as a powerful model for studying neurogenesis, pluripotency, and transcriptional regulation during early embryonic development. It is also used to investigate mechanisms of cell fate decisions, stem cell biology, and congenital neurological disorders.

Application Notes

Optimal dilution of the Zebrafish Sox3 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Sox3 recombinant protein (amino acids Q141-Q285) was used as the immunogen for the Zebrafish Sox3 antibody.

Storage

After reconstitution, the Zebrafish Sox3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.