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Home >> Antibodies >> Zebrafish Lin7c Antibody / Protein lin-7 homolog C

Zebrafish Lin7c Antibody / Protein lin-7 homolog C (RZ1153)

  Catalog No Formulation Size Price (USD)  
Image RZ1153 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 539
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Western blot analysis of Lin7c protein using Zebrafish Lin7c antibody and zebrafish embryo tissue lysate. The predicted molecular weight of LIN7C is ~22 kDa.
Availability 2-3 weeks
Species Reactivity Zebrafish
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity chromatography
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q66IB0
Applications Western Blot : 0.5-1 ug/ml
Limitations This Zebrafish Lin7c antibody is available for research use only.
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Description

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Application Notes

Optimal dilution of the Zebrafish Lin7c antibody should be determined by the researcher.

Immunogen

An E.coli-derived zebrafish Lin7c recombinant protein (amino acids M1-A73) was used as the immunogen for the Zebrafish Lin7c antibody.

Storage

After reconstitution, the Zebrafish Lin7c antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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