Zebrafish Lhcgr Antibody / Lutropin-choriogonadotropic hormone receptor (RZ1187)

Description

Luteinizing hormone/choriogonadotropin receptor (Lhcgr) is a G protein-coupled receptor that mediates the actions of luteinizing hormone (LH) and chorionic gonadotropin (CG). In zebrafish (Danio rerio), Lhcgr plays a crucial role in gonadal development and function, including steroidogenesis, oocyte maturation, and ovulation.

Zebrafish lhcgr is primarily expressed in the gonads, where it facilitates LH signaling necessary for reproductive maturation and fertility. Activation of Lhcgr triggers downstream signaling cascades, including cAMP/PKA pathways, leading to the production of sex steroids such as estradiol and testosterone. Functional studies in zebrafish have shown that Lhcgr is essential for proper follicular development and ovulation in females, and for Leydig cell function in males.

As a conserved reproductive hormone receptor, zebrafish Lhcgr is a valuable model for investigating vertebrate reproductive endocrinology, hormone receptor signaling, and the genetic basis of fertility and gonadal disorders.

Application Notes

Optimal dilution of the Zebrafish Lhcgr antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Lhcgr recombinant protein (amino acids V51-V708) was used as the immunogen for the Zebrafish Lhcgr antibody.

Storage

After reconstitution, the Zebrafish Lhcgr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.