Zebrafish Ints12 Antibody / Integrator complex subunit 12 (RZ1025)

Description

Ints12 is a component of the integrator complex, a multiprotein complex that plays a vital role in the 3'-end processing of small nuclear RNAs (snRNAs) and in transcriptional regulation by RNA polymerase II. Zebrafish Ints12 is the ortholog of human INTS12, sharing significant sequence and functional conservation. This evolutionary relationship makes zebrafish a valuable model for studying the conserved biological roles of INTS12 in RNA processing and gene expression regulation across vertebrates.

Zebrafish Ints12 is essential for embryonic development and cellular homeostasis. Disruption of Ints12 function has been linked to defects in RNA maturation and transcriptional control, processes that are critical for neural development, hematopoiesis, and organogenesis. In humans, mutations in INTS12 have been associated with rare syndromic conditions and developmental anomalies, further underscoring the gene's biological significance.

The Zebrafish Ints12 antibody is an essential reagent for researchers studying RNA processing mechanisms and transcriptional regulation in vertebrate development. With proven utility in immunohistochemistry, western blot, and immunofluorescence applications, the Zebrafish Ints12 antibody allows for specific detection of Ints12 expression in various tissues. Incorporating the Zebrafish Ints12 antibody into experimental workflows facilitates detailed analysis of integrator complex dynamics and enhances our understanding of gene regulatory networks in vivo.

Application Notes

Optimal dilution of the Zebrafish Ints12 antibody should be determined by the researcher.

Immunogen

An E.coli-derived zebrafish Ints12 recombinant protein (amino acids M1-K394) was used as the immunogen for the Zebrafish Ints12 antibody.

Storage

After reconstitution, the Zebrafish Ints12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.