Zebrafish Hmox1a Antibody / Hmox1 / Heme oxygenase (RZ1193)

Description

Heme oxygenase 1a (Hmox1a) is one of the zebrafish homologs of the mammalian heme oxygenase 1 (HMOX1), an essential enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide. In zebrafish (Danio rerio), Hmox1a plays a critical role in oxidative stress response, iron homeostasis, and anti-inflammatory signaling, and is a key marker of cellular stress.

Hmox1a is inducible under a variety of stress conditions, including oxidative damage, hypoxia, heavy metal exposure, and inflammation. Its expression is regulated by transcription factors such as Nrf2 and Bach1. Zebrafish hmox1a is highly conserved and is expressed in multiple tissues including the liver, kidney, and vasculature, especially under stress or injury.

Zebrafish provide a powerful in vivo model for studying Hmox1a function in developmental biology, toxicology, inflammation, and iron metabolism. Because of its conservation with mammalian HMOX1, hmox1a is widely used in research on antioxidant defense, redox signaling, and as a readout for environmental and pharmaceutical stress responses.

Application Notes

Optimal dilution of the Zebrafish Hmox1a antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Hmox1a recombinant protein (amino acids M1-K244) was used as the immunogen for the Zebrafish Hmox1a antibody.

Storage

After reconstitution, the Zebrafish Hmox1a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.