Zebrafish Cyp17a1 Antibody (RZ1214)

Description

Cyp17a1, or cytochrome P four five zero family seventeen subfamily A polypeptide one, is a critical enzyme involved in the biosynthesis of steroid hormones. In zebrafish, Cyp17a1 performs both seventeen alpha hydroxylase and seventeen twenty lyase activities, enabling the production of key intermediates for the synthesis of glucocorticoids and sex steroids.

Cyp17a1 is predominantly expressed in steroidogenic tissues such as the interrenal gland, gonads, and brain. During development, it is required for the proper formation of the endocrine system and plays a vital role in processes such as stress regulation, sexual differentiation, and reproduction. By controlling the production of hormones like cortisol, testosterone, and estradiol, Cyp17a1 supports a wide range of physiological functions including metabolism, immune regulation, and fertility.

Because of its conserved enzymatic role and tissue-specific expression, zebrafish Cyp17a1 is frequently used as a model to study endocrine system development, steroid hormone biosynthesis, and the impact of environmental or pharmaceutical compounds on hormone production. It is also valuable for research into adrenal and gonadal disorders.

Application Notes

Optimal dilution of the Zebrafish Cyp17a1 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Cyp17a1 recombinant protein (amino acids Q67-C519) was used as the immunogen for the Zebrafish Cyp17a1 antibody.

Storage

After reconstitution, the Zebrafish Cyp17a1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.