Zebrafish Cxcl8a Antibody / Il-8 (RZ1212)

Description

Cxcl8a, also known as Il-8 like a, is a chemokine that plays a key role in mediating the immune response, particularly by promoting the recruitment and activation of neutrophils. In zebrafish, Cxcl8a is a functional homolog of mammalian interleukin eight and is critical for the early innate immune defense against infection and tissue injury.

Cxcl8a is produced by various cell types in response to inflammatory stimuli and acts through Cxcr receptors to direct the migration of neutrophils to sites of inflammation. In zebrafish embryos and larvae, Cxcl8a expression is rapidly upregulated following bacterial challenge, physical injury, or exposure to immune-modulating compounds.

Due to the transparency and genetic tractability of zebrafish, Cxcl8a is widely used as a model to study inflammation, immune cell dynamics, and host pathogen interactions in vivo. It serves as a valuable biomarker for inflammation and is an important tool for investigating the effects of immunomodulatory drugs and environmental stressors.

Application Notes

Optimal dilution of the Zebrafish Cxcl8a antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Cxcl8a recombinant protein (amino acids M23-P98) was used as the immunogen for the Zebrafish Cxcl8a antibody.

Storage

After reconstitution, the Zebrafish Cxcl8a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.