Zebrafish Bdnf Antibody / Brain-derived neurotrophic factor (RZ1177)

Description

Brain-derived neurotrophic factor (Bdnf) is a key member of the neurotrophin family, which plays a vital role in the development, maintenance, and plasticity of the nervous system. In zebrafish (Danio rerio), the bdnf gene encodes a protein highly conserved with its mammalian counterpart, sharing significant sequence and functional homology. Bdnf is critically involved in promoting the survival and differentiation of neurons, synaptic plasticity, and modulation of neurogenesis during development and in the adult brain.

Expression of Bdnf in zebrafish is observed early in embryogenesis and persists in various regions of the central nervous system, including the forebrain, optic tectum, and spinal cord. Zebrafish Bdnf interacts primarily with the high-affinity receptor TrkB (Ntrk2), activating intracellular signaling pathways such as PI3K-Akt, MAPK/ERK, and PLC-γ, which are essential for neurotrophic support and synaptic function.

Due to the genetic tractability and optical transparency of zebrafish embryos, this model organism is widely used to investigate Bdnf-mediated neuronal development, behavior, and regeneration. Studies have also linked altered bdnf expression to stress responses, learning, and memory in zebrafish, highlighting its relevance in neurodevelopmental and neuropsychiatric research.

Application Notes

Optimal dilution of the Zebrafish Bdnf antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Bdnf recombinant protein (amino acids A27-R278) was used as the immunogen for the Zebrafish Bdnf antibody.

Storage

After reconstitution, the Zebrafish Bdnf antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.