Zebrafish Alcama Antibody / Neurolin (RZ1201)

Description

Activated leukocyte cell adhesion molecule a (Alcama), also known as Neurolin, is a member of the immunoglobulin superfamily of cell adhesion molecules. In zebrafish (Danio rerio), Alcama plays a vital role in axon guidance, cell-cell adhesion, and tissue morphogenesis, particularly during the development of the nervous system, vasculature, and hematopoietic system.

Alcama is prominently expressed in developing neurons, where it mediates axon fasciculation and growth cone navigation, facilitating the formation of organized neuronal tracts. In addition to its role in neurodevelopment, zebrafish Alcama is expressed in vascular endothelial cells and hematopoietic stem and progenitor cells (HSPCs), where it contributes to vasculogenesis, vascular remodeling, and stem cell niche formation.

Due to its conserved structure and multifunctional roles, zebrafish Alcama is a valuable model for studying cell adhesion dynamics, nervous system wiring, hematopoietic development, and angiogenesis. It is also used in research related to immune cell migration, axon pathfinding disorders, and regenerative medicine.

Application Notes

Optimal dilution of the Zebrafish Alcama antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Alcama recombinant protein (amino acids K54-I509) was used as the immunogen for the Zebrafish Alcama antibody.

Storage

After reconstitution, the Zebrafish Alcama antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.