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The primary site of action of cytochalasin B on cell motility processes is beta-actin. Habets et al.(1992) generated hybrids that harbor only specific regions of human chromosome 7 and assigned the ACTB locus to 7p15-p12. ACTB and the other assigned beta-actin-related sequences are dispersed over at least four different chromosomes including one locus assigned to the X chromosome. A mutation of beta-actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.
Optimal dilution of the Zebrafish Actba antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the N-terminus of zebrafish Beta actin/Actba was used as the immunogen for the Zebrafish Actba antibody.
After reconstitution, the Zebrafish Actba antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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