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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TULP3 Antibody / Tubby-related protein 3 (RQ7673)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7673 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | O75386 |
| Localization | Nuclear, cell projections, cytoplasm |
| Applications | Western Blot : 0.5-1ug/ml Direct ELISA : 0.1-0.5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This TULP3 antibody is available for research use only. |
|
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TULP3 antibody is used in research focused on intracellular trafficking and ciliary biology. The encoded protein, tubby-related protein 3, belongs to the tubby-like protein family, which is characterized by a conserved C-terminal tubby domain that facilitates binding to phosphoinositides and transcriptional regulation. TULP3 has emerged as an important adaptor that links membrane-associated cargo to the intraflagellar transport (IFT) machinery, a process critical for the proper localization of G protein-coupled receptors (GPCRs) and other signaling molecules within primary cilia.
TULP3 functions by bridging membrane proteins with the IFT-A complex, ensuring their transport into cilia. This activity is essential for regulating ciliary signaling pathways, including the Hedgehog pathway, which controls embryonic development, tissue patterning, and stem cell maintenance. Disruption of TULP3 function interferes with the trafficking of GPCRs, leading to defective ciliary signaling and contributing to developmental abnormalities and disease.
Genetic studies have linked TULP3 deficiency to ciliopathies, a group of disorders caused by defects in ciliary structure or function. These include conditions marked by neural tube defects, skeletal malformations, and organ developmental anomalies. The role of TULP3 in GPCR trafficking also suggests relevance in neurological signaling, as proper receptor distribution is crucial for synaptic function and neuronal communication. Its emerging importance in human health has made TULP3 a subject of growing interest in developmental biology and disease modeling.
On a molecular level, TULP3 contains a tubby domain that anchors it to phosphoinositide-rich membranes and an N-terminal region that binds the IFT-A complex. This dual functionality positions TULP3 as a key mediator of ciliary protein targeting. Research indicates that loss of TULP3 not only affects ciliary GPCRs but also alters signaling cascades that regulate growth, differentiation, and survival.
The TULP3 antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to evaluate protein expression, subcellular localization, and disease-associated changes. These applications provide insight into how TULP3 regulates trafficking mechanisms and ciliary function. For investigators studying primary cilia, developmental disorders, or signaling pathways reliant on GPCR distribution, the TULP3 antibody is an indispensable research tool. NSJ Bioreagents offers rigorously validated antibodies that support reproducibility and accuracy in advanced studies.
Optimal dilution of the TULP3 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids P62-H362) was used as the immunogen for the TULP3 antibody.
After reconstitution, the TULP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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