- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TIMM22 Antibody / Translocase of inner mitochondrial membrane 22 [clone 31T40] (FY12608)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12608 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
| Availability | 2-3 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 31T40 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | Q9Y584 |
| Applications | Western Blot : 1:500-1:2000 |
| Limitations | This TIMM22 antibody is available for research use only. |
|
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TIMM22 antibody detects translocase of inner mitochondrial membrane 22, a mitochondrial import protein encoded by the TIMM22 gene. TIMM22 is part of the TIM22 complex, which mediates insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. It recognizes hydrophobic precursor proteins delivered by the small TIM chaperone complex and inserts them into the inner membrane in an energy-dependent process. Through this activity, TIMM22 ensures proper biogenesis of mitochondrial carriers and maintenance of energy metabolism.
TIMM22 antibody is widely applied in mitochondrial biology and protein trafficking research. By detecting TIMM22, scientists can study how mitochondrial import machinery regulates oxidative phosphorylation and cellular energy production. Defects in TIMM22 function lead to impaired assembly of carrier proteins such as ADP/ATP translocases, disrupting mitochondrial function and cellular homeostasis.
Western blot assays detect TIMM22 protein in mitochondrial fractions, while immunohistochemistry highlights expression in tissues with high metabolic demand such as muscle, heart, and brain. Immunofluorescence reveals punctate mitochondrial staining, consistent with its localization in the inner membrane. These methods allow precise analysis of mitochondrial import processes.
Mutations in TIMM22 and disruption of mitochondrial protein import are linked to metabolic disorders, neurodegeneration, and cardiomyopathy. By applying TIMM22 antibody, researchers can investigate how defects in import machinery contribute to disease and explore therapeutic strategies to restore mitochondrial function.
TIMM22 antibody from NSJ Bioreagents provides dependable specificity for studying mitochondrial protein import and energy metabolism. Its strong performance across applications ensures accurate detection of TIMM22 in diverse biological systems.
Optimal dilution of the TIMM22 antibody should be determined by the researcher.
A synthesized peptide derived from human TIMM22 was used as the immunogen for the TIMM22 antibody.
Store the TIMM22 antibody at -20oC.
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