• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> RMI2 Antibody / BLAP18 / RecQ-mediated genome instability protein 2

RMI2 Antibody / BLAP18 / RecQ-mediated genome instability protein 2 (RQ8809)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image RQ8809 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
Bulk quote request
Western blot testing of 1) human 293T, 2) human MCF7, 3) human HT-1080, 4) human HeLa, 5) rat thymus and 6) mouse thymus tissue lysate with RMI2 antibody. Expected molecular weight ~18 kDa.
Western blot testing of 1) human 293T, 2) human MCF7, 3) human HT-1080, 4) human HeLa, 5) rat thymus and 6) mouse thymus tissue lysate with RMI2 antibody. Expected molecular weight ~18 kDa.
Availability 1-3 days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity chromatography
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q96E14
Applications Western Blot : 1-2ug/ml
ELISA : 0.1-0.5ug/ml
Limitations This RMI2 antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

Description

RMI2 is a component of the BLM (RECQL3) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability. This gene is mapped to 16p13.13. RMI1 and RMI2 were present in approximately stoichiometric amounts with other BLM complex components, including topoisomerase-3-alpha (TOP3A), RPA (see RPA1), and BLAP250. RMI2 also associated with RMI1 and TOP3A in a second complex. RMI1 and RMI2 interacted directly, and both were essential for stability of the BLM complex. Depletion of either RMI1 or RMI2 depleted the other protein by 80 to 90%. Chicken DT40 cells depleted of Rmi2 displayed elevated sister chromatid exchange, but other functions of the BLM complex appeared intact. Mutation analysis revealed that interaction between human RMI2 and BLM was essential for suppression of sister chromatid exchange.

Application Notes

Optimal dilution of the RMI2 antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (amino acids L23-P147) was used as the immunogen for the RMI2 antibody.

Storage

After reconstitution, the RMI2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Related Products

   1.   View all RMI2 antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.