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Home >> Antibodies >> Recombinant Tumor Protein 53 Antibody / p53

Recombinant Tumor Protein 53 Antibody / p53 [clone TP53/8183R] (V5803)

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  Catalog No Formulation Size Price (USD)  
Image V5803-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5803-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5803SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human ovarian carcinoma tissue with recombinant Tumor Protein 53 antibody (clone TP53/8183R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human ovarian carcinoma tissue with recombinant Tumor Protein 53 antibody (clone TP53/8183R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant Tumor Protein 53 antibody (clone TP53/8183R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name TP53/8183R
Purity Protein A affinity
UniProt P04637
Localization Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant Tumor Protein 53 antibody is available for research use only.
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Description

p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Application Notes

Optimal dilution of the recombinant Tumor Protein 53 antibody should be determined by the researcher.

Immunogen

A recombinant human full-length TP53 protein was used as the immunogen for the recombinant Tumor Protein 53 antibody.

Storage

Aliquot the recombinant Tumor Protein 53 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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