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Home >> Antibodies >> Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein

Recombinant TDP43 Antibody / TARDBP / TAR DNA binding protein [clone TARDP/9299R] (V5595)

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  Catalog No Formulation Size Price (USD)  
Image V5595-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5595-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5595SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
Microvalidated Recrabbitmono
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IHC staining of FFPE human prostate tissue with recombinant TDP43 antibody (clone TARDP/9299R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human prostate tissue with recombinant TDP43 antibody (clone TARDP/9299R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant TDP43 antibody (clone TARDP/9299R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name TARDP/9299R
Purity Protein A/G affinity
UniProt Q13148
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant TDP43 antibody is available for research use only.
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Description

TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

Application Notes

Optimal dilution of the recombinant TDP43 antibody should be determined by the researcher.

Immunogen

A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.

Storage

Aliquot the recombinant TDP43 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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