- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant PMS2 antibody detects PMS2, a mismatch repair endonuclease encoded by the PMS2 gene. PMS2 partners with MLH1 to form the MutLα complex, which coordinates repair of DNA replication errors. Because mutations in PMS2 are linked to Lynch syndrome and other cancers, Recombinant PMS2 antibody is widely used in oncology, genetics, and DNA repair research.
PMS2 contains an ATPase domain and an endonuclease domain, enabling recognition and repair of mismatched bases during replication. The PMS2-MLH1 heterodimer interacts with MutSα and MutSβ complexes to initiate repair, preventing mutation accumulation. Loss of PMS2 function destabilizes the mismatch repair system, resulting in microsatellite instability and increased cancer risk, particularly in colorectal and endometrial carcinomas.
The Recombinant PMS2 antibody clone PMS2/4373R provides specific and reproducible detection. Recombinant technology ensures batch-to-batch uniformity, which is essential in long-term studies. Clone PMS2/4373R has been cited in peer-reviewed research on DNA repair mechanisms, mismatch repair deficiency, and cancer diagnostics. Its applications include immunohistochemistry, immunoblotting, and molecular pathology assays.
Research using clone PMS2/4373R has demonstrated how PMS2 loss serves as a diagnostic marker for mismatch repair deficiency and Lynch syndrome. In oncology, detection of PMS2 guides treatment decisions, particularly regarding immunotherapy response in tumors with microsatellite instability. Studies have also shown PMS2 involvement in broader DNA damage responses, linking it to genome integrity and stability.
NSJ Bioreagents supplies this Recombinant PMS2 antibody to support oncology, genetics, and DNA repair biology. Alternate designations include PMS2 endonuclease antibody, postmeiotic segregation increased 2 protein antibody, mismatch repair protein antibody, MutL homolog antibody, and Lynch syndrome marker antibody.
Optimal dilution of the recombinant PMS2 antibody should be determined by the researcher.
A portion of amino acids 1-100 from the human protein was used as the immunogen for the recombinant PMS2 antibody.
Store the recombinant PMS2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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