- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant Galectin 1 antibody detects galectin-1, a member of the galectin family of beta-galactoside-binding proteins encoded by the LGALS1 gene. Galectin-1 is widely expressed and regulates diverse cellular processes including apoptosis, immune modulation, angiogenesis, and extracellular matrix remodeling. Because of its dual role in normal physiology and disease, Recombinant Galectin 1 antibody is a versatile reagent in immunology, cancer biology, and developmental research.
Galectin-1 is a homodimeric protein of approximately 14 kDa per subunit. Each monomer contains a carbohydrate recognition domain that binds beta-galactosides on glycoproteins and glycolipids. Through these interactions, galectin-1 crosslinks receptors and organizes glycoprotein lattices, influencing signaling, adhesion, and migration. It also binds extracellular matrix components such as laminin and fibronectin, linking it to tissue remodeling.
The Recombinant Galectin 1 antibody clone GAL1/2499R provides consistent and specific detection. Recombinant production ensures batch-to-batch reproducibility, which is critical for long-term studies. Clone GAL1/2499R has been cited in peer-reviewed publications exploring immune tolerance, tumor progression, and neuronal survival. Its performance in immunohistochemistry, Western blotting, and flow cytometry makes it broadly useful across experimental systems.
Research using clone GAL1/2499R has highlighted galectin-1 as a potent immunoregulatory molecule. It induces apoptosis of activated T cells, promotes regulatory T-cell expansion, and suppresses inflammatory responses. In oncology, galectin-1 expression correlates with tumor angiogenesis, immune evasion, and metastasis. Blocking galectin-1 signaling is being studied as a therapeutic strategy to enhance anti-tumor immunity. Beyond pathology, galectin-1 supports neural development and regeneration, where its trophic effects help maintain neuron survival and plasticity.
NSJ Bioreagents provides this Recombinant Galectin 1 antibody to support research in immunology, oncology, and neuroscience. Alternate terms include LGALS1 antibody, beta-galactoside-binding protein antibody, galaptin antibody, HBL-6 antibody, and lectin galactoside-binding soluble 1 antibody.
Titering of the recombinant Galectin 1 antibody may be required for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A human recombinant partial protein corresponding to amino acids 12-108 was used as the immunogen for the recombinant Galectin 1 antibody.
Store the recombinant Galectin 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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