- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CD3e Antibody / CD3 epsilon [clone C3e/3125R] (V7557)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7557-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V7557-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
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V7557SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | C3e/3125R |
| Purity | Protein A affinity chromatography |
| UniProt | P07766 |
| Localization | Cell surface, cytoplasmic |
| Applications | ELISA (order BSA-free Format For Coating) : Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant CD3e antibody is available for research use only. |
|
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Recombinant CD3e antibody detects CD3 epsilon, a component of the CD3 complex encoded by the CD3E gene. CD3 epsilon is an integral part of the T-cell receptor complex, which is essential for antigen recognition and T-cell activation. Because CD3 is expressed on nearly all mature T cells, Recombinant CD3e antibody is an indispensable tool in immunology, oncology, and diagnostic research.
The CD3 complex includes CD3 epsilon, gamma, delta, and zeta chains, which associate with the T-cell receptor alpha and beta chains. CD3 epsilon contains immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic tail, which initiate signaling upon T-cell receptor engagement. These motifs recruit kinases such as Lck and Zap70, triggering cascades that regulate proliferation, differentiation, and cytokine production.
The Recombinant CD3e antibody clone C3e/3125R provides consistent and specific recognition. Recombinant production ensures reproducibility across batches, minimizing variability in long-term studies. Clone C3e/3125R has been referenced in peer-reviewed publications investigating T-cell signaling, thymocyte development, and immunotherapy. Its specificity makes it suitable for flow cytometry, immunohistochemistry, and functional assays of T-cell activation.
Research using clone C3e/3125R has demonstrated how CD3 epsilon expression is indispensable for T-cell development in the thymus and for peripheral immune responses. In oncology, CD3 detection helps characterize tumor-infiltrating lymphocytes and supports the development of bispecific antibodies and CAR T-cell therapies that rely on CD3 engagement. Beyond cancer, CD3 studies are central to understanding autoimmunity, infectious disease, and transplant rejection, where T-cell activity is a determining factor.
NSJ Bioreagents supplies this Recombinant CD3e antibody to support T-cell biology, immunotherapy, and diagnostic applications. Alternate names include CD3E antibody, T-cell surface glycoprotein CD3 epsilon chain antibody, T-cell receptor-associated protein epsilon antibody, T-cell receptor signaling component antibody, and thymocyte differentiation antigen antibody.
Optimal dilution of the recombinant CD3e antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 23-119) was used as the immunogen for the recombinant CD3e antibody.
Store the recombinant CD3e antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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