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Home >> Antibodies >> Recombinant BRCA1 Antibody

Recombinant BRCA1 Antibody [clone BRCA1/13502R] (V5798)

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  Catalog No Formulation Size Price (USD)  
Image V5798-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5798-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5798SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
Microvalidated Recrabbitmono
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IHC staining of FFPE human testis tissue with recombinant BRCA1 antibody (clone BRCA1/13502R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human testis tissue with recombinant BRCA1 antibody (clone BRCA1/13502R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name BRCA1/13502R
Purity Protein A affinity
UniProt P38398
Localization Chromosome, Cytoplasm, Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant BRCA1 antibody is available for research use only.
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Description

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Application Notes

Optimal dilution of the recombinant BRCA1 antibody should be determined by the researcher.

Immunogen

A recombinant fragment corresponding to the N-terminal region of human BRCA1 protein was used as the immunogen for the recombinant BRCA1 antibody.

Storage

Aliquot the recombinant BRCA1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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