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Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins and functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). [UniProt]
Optimal dilution of the Phospho-mTOR antibody should be determined by the researcher.
A synthetic peptide specific to the region of human mTOR protein surrounding phosphorylated serine 2448 was used as the immunogen for the Phospho-mTOR antibody (pS2448).
Store the Phospho-mTOR antibody at -20oC.
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