- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
OTX2 Antibody / Orthodenticle homolog 2 [clone PCRP-OTX2-1E10] (V5537)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5537-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V5537-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
|
V5537SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, |
| Clone Name | PCRP-OTX2-1E10 |
| Purity | Protein A/G affinity |
| UniProt | P32243 |
| Localization | Nucleus |
| Applications | Flow Cytometry : 1-2ug/million cells |
| Limitations | This OTX2 antibody is available for research use only. |
|
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Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.
Optimal dilution of the OTX2 antibody should be determined by the researcher.
Recombinant human full-length OTX2 protein was used as the immunogen for the OTX2 antibody.
Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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