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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MTCH2 Antibody / Mitochondrial carrier homolog 2 (FY13035)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13035 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
MTCH2 antibody detects Mitochondrial carrier homolog 2, a mitochondrial outer membrane protein involved in metabolism, apoptosis regulation, and mitochondrial dynamics. The UniProt recommended name is Mitochondrial carrier homolog 2 (MTCH2). Although originally classified as a putative solute carrier, MTCH2 primarily functions as a regulator of mitochondrial morphology and cell death signaling.
Functionally, MTCH2 antibody identifies a 305-amino-acid protein localized to the mitochondrial outer membrane. MTCH2 interacts with pro-apoptotic proteins such as BID and regulates mitochondrial outer membrane permeabilization (MOMP) during apoptosis. It modulates the recruitment and activation of truncated BID (tBID), a key step in BAX and BAK activation leading to cytochrome c release and caspase activation. Thus, MTCH2 serves as a checkpoint controlling apoptosis sensitivity.
The MTCH2 gene is located on chromosome 11p11.2 and encodes a protein expressed in metabolically active tissues including brain, liver, and skeletal muscle. MTCH2 contains six predicted transmembrane helices and shares limited homology with mitochondrial carrier family proteins, though it lacks classical solute transport function. Instead, it influences mitochondrial bioenergetics and lipid metabolism through protein-protein interactions at the outer membrane.
In addition to apoptosis, MTCH2 plays roles in energy metabolism and mitochondrial fission-fusion balance. It has been shown to interact with mitochondrial fission regulator DRP1 and influence cristae remodeling under metabolic stress. Genetic studies have associated MTCH2 variants with obesity and metabolic syndrome, suggesting that it contributes to energy balance by regulating mitochondrial efficiency and lipid oxidation.
In neuronal and immune systems, MTCH2 contributes to mitochondrial trafficking and immune cell activation. Overexpression of MTCH2 sensitizes cells to apoptotic stimuli, while its depletion can promote survival under stress conditions. Its dual role in metabolism and apoptosis underscores its function as a metabolic gatekeeper linking mitochondrial function to cell fate decisions.
MTCH2 antibody is widely used in mitochondrial biology, apoptosis, and metabolism research. It is suitable for western blotting, immunocytochemistry, and co-immunoprecipitation to study MTCH2 localization and interaction networks. This antibody supports studies of mitochondrial outer membrane regulation, lipid metabolism, and programmed cell death. In disease research, it assists in examining MTCH2's contribution to metabolic disorders and neurodegeneration.
Structurally, MTCH2 contains conserved hydrophobic transmembrane helices that form a scaffold for protein binding. It lacks the canonical carrier signature motifs found in other mitochondrial carriers, reflecting its specialized signaling function. NSJ Bioreagents provides MTCH2 antibody reagents validated for use in apoptosis, mitochondrial function, and metabolic regulation research.
Optimal dilution of the MTCH2 antibody should be determined by the researcher.
E.coli-derived human MTCH2 recombinant protein (Position: M1-I303) was used as the immunogen for the MTCH2 antibody.
After reconstitution, the MTCH2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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