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Home >> Antibodies >> Lamin A/C Antibody

Lamin A/C Antibody [clone 1073CT3.1.3] (F54082)

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  Catalog No Formulation Size Price (USD)  
Image F54082-0.2ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.2 ml 429
Image
F54082-0.05ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.05 ml 199
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Western blot testing of Lamin A/C antibody at 1:4000: Lane 1) human HeLa, 2) rat C6, 3) mouse L929 and 4) mouse NIH3T3 cell lysate. Predicted molecular weight ~74 & 65 kDa.
Western blot testing of Lamin A/C antibody at 1:4000: Lane 1) human HeLa, 2) rat C6, 3) mouse L929 and 4) mouse NIH3T3 cell lysate. Predicted molecular weight ~74 & 65 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 1073CT3.1.3
Purity Protein G purified
UniProt P02545
Applications Western Blot : 1:4000
Limitations This Lamin A/C antibody is available for research use only.
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Description

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. [UniProt]

Application Notes

The stated application concentrations are suggested starting points. Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Recombinant human LMNA was used as the immunogen for the Lamin A/C antibody.

Storage

Aliquot the LMNA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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