Krueppel-like factor 4 Antibody / KLF4 (RQ6883)

Description

KKrueppel-like factor 4 (KLF4) is a zinc finger transcription factor that regulates a wide range of cellular processes, including proliferation, differentiation, and survival. As a member of the Krueppel-like factor family, it binds GC-rich DNA sequences and influences the expression of genes involved in epithelial biology, stem cell maintenance, and tissue regeneration. A Krueppel-like factor 4 antibody is commonly used to study transcriptional regulation and cellular identity in normal physiology and disease.

KLF4 plays dual roles in cancer biology. It can act as a tumor suppressor by promoting differentiation and inhibiting uncontrolled proliferation, but in other contexts it contributes to tumor progression by supporting cell survival and resistance to stress. This context-dependent behavior has made it a focal point of studies in oncology. Employing a Krueppel-like factor 4 antibody allows researchers to analyze its expression patterns and functional consequences in diverse cancer models.

KLF4 is also well known as one of the original Yamanaka factors, along with OCT4, SOX2, and c-MYC, used to reprogram somatic cells into induced pluripotent stem cells (iPSCs). Its ability to regulate pluripotency and stemness has made it a valuable marker in stem cell research and regenerative medicine. Using a Krueppel-like factor 4 antibody enables scientists to track its role in reprogramming and cell fate determination.

NSJ Bioreagents provides a high-quality Krueppel-like factor 4 antibody validated for applications such as western blot, immunohistochemistry, and chromatin immunoprecipitation. Selecting a Krueppel-like factor 4 antibody from NSJ Bioreagents ensures sensitivity and reproducibility in studies of transcriptional regulation, stem cell biology, and cancer research.

Application Notes

Optimal dilution of the Krueppel-like factor 4 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids M1-H389) was used as the immunogen for the Krueppel-like factor 4 antibody.

Storage

After reconstitution, the Krueppel-like factor 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.