IRF9 Antibody / Interferon regulatory factor 9 (R32622)

Description

IRF9 (Interferon regulatory factor 9) is a key transcriptional regulator involved in the type I interferon signaling pathway. It forms a complex with STAT1 and STAT2 known as ISGF3 (interferon-stimulated gene factor 3), which translocates to the nucleus to activate transcription of interferon-stimulated genes (ISGs). This pathway plays a crucial role in antiviral defense, immune modulation, and inflammatory responses.

IRF9 is expressed in various immune and non-immune cells and is upregulated in response to interferon stimulation. It is essential for proper immune responses to viral infection and has been studied in the context of host–pathogen interactions, autoimmune conditions, and cancer immunology. Its central role in IFN signaling makes it a reliable marker for assessing cellular response to cytokine stimulation.

The IRF9 antibody is a powerful tool for detecting endogenous IRF9 in applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the IRF9 antibody from NSJ Bioreagents to study the dynamics of interferon signaling, examine protein expression across tissues, and explore transcriptional regulation under immune challenge. With high specificity and consistent performance, the IRF9 antibody supports advanced research in immunology, virology, and cytokine signaling networks.

Application Notes

Optimal dilution of the IRF9 antibody should be determined by the researcher.

Immunogen

A human recombinant protein corresponding to amino acids M1-K110 was used as the immunogen for the IRF9 antibody.

Storage

After reconstitution, the IRF9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.