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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Interferon gamma receptor 1 Antibody / Ifngr1 (RQ8495)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8495 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
|
| Availability | 1-3 days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P15261 |
| Applications | Western Blot : 0.5-1ug/ml ELISA : 0.1-0.5ug/ml |
| Limitations | This Interferon gamma receptor 1 antibody is available for research use only. |
|
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Interferon gamma receptor 1 (IFNGR1) also known as CD119 (Cluster of Differentiation 119), is a protein that in humans is encoded by the IFNGR1 gene. IFN-gamma plays key roles in both the innate and adaptive immune response. IFN-gamma activates the cytotoxic activity of innate immune cells, such as macrophages and NK cells. IFN-gamma production by NK cells and antigen presenting cells (APCs) promotes cell-mediated adaptive immunity by inducing IFN-gamma production by T lymphocytes, increasing class I and class II MHC expression, and enhancing peptide antigen presentation. Due to differences in the degree of glycosylation, there are 3 forms of IFN-gamma, with approximate molecular weights of 25, 20, and 15.5 kDa by SDS-PAGE. The anti-viral activity of IFN-gamma is due to its induction of PKR and other regulatory proteins. Binding of IFN-gamma to the IFNGR1/IFNGR2 complex promotes dimerization of the receptor complexes to form the (IFNGR1/IFNGR2)2 -IFN-gamma dimer. Binding induces a conformational change in receptor intracellular domains and signaling involves Jak1, Jak2, and Stat1. The critical role of IFN-gamma in amplification of immune surveillance and function is supported by increased susceptibility to pathogen infection by IFN-gamma or IFNGR knockout mice and in humans with inactivating mutations in IFNGR1 or IFNGR2. IFN-gamma also appears to have a role in atherosclerosis.
Optimal dilution of the Interferon gamma receptor 1 antibody should be determined by the researcher.
An E.coli-derived mouse recombinant protein (amino acids L45-Q347) was used as the immunogen for the Interferon gamma receptor 1 antibody.
After reconstitution, the Interferon gamma receptor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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