Insulin-like growth factor-binding protein 3 Antibody / IGFBP3 [clone IGFBP3/3423] (V5370)

Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Insulin-like growth factor-binding protein 3 antibody (clone IGFBP3/3423). These results demonstrate the foremost specificity of the IGFBP3/3423 mAb. Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (clone MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

IHC staining of FFPE human placenta tissue with Insulin-like growth factor-binding protein 3 antibody (clone IGFBP3/3423). Inset: PBS used in place of primary Ab (secondary Ab negative control).

SDS-PAGE analysis of purified, BSA-free Insulin-like growth factor-binding protein 3 antibody (clone IGFBP3/3423) as confirmation of integrity and purity.