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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Hsp70 Antibody / Heat shock protein 70 / HSPA8 [clone 31H87] (FY13333)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13333 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
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Hsp70 antibody detects Heat shock cognate protein 70, also known as HSC70, encoded by the HSPA8 gene. Heat shock cognate protein 70 is a constitutively expressed member of the Hsp70 family of molecular chaperones that regulate protein folding, quality control, and degradation. Hsp70 antibody provides researchers with a highly specific reagent for studying stress responses, proteostasis, and disease mechanisms associated with protein misfolding.
Heat shock cognate protein 70 binds nascent polypeptides, unfolded proteins, and misfolded intermediates in an ATP dependent cycle. Research using Hsp70 antibody has shown that HSC70 cooperates with Hsp40 co chaperones and nucleotide exchange factors to stabilize client proteins, facilitate folding, and prevent aggregation. This activity is essential for maintaining proteome stability during protein synthesis and cellular stress.
Studies with Hsp70 antibody have revealed roles in intracellular protein transport. Heat shock cognate protein 70 participates in clathrin mediated endocytosis by uncoating clathrin coated vesicles, ensuring efficient trafficking of receptors and cargo. It also contributes to nuclear import, mitochondrial translocation, and protein transport across membranes. These findings highlight the broad role of HSC70 in protein logistics within the cell.
Beyond folding and trafficking, Heat shock cognate protein 70 is a central regulator of chaperone mediated autophagy. Research using Hsp70 antibody has demonstrated that HSC70 recognizes proteins containing KFERQ like motifs and directs them to lysosomes for degradation. This selective autophagy pathway maintains cellular homeostasis by removing damaged or superfluous proteins. Dysregulation of this pathway contributes to age related disease and neurodegeneration.
HSC70 also supports cellular survival under stress. Studies with Hsp70 antibody have shown that its levels increase during stress conditions, such as oxidative stress, heat shock, or metabolic imbalance. By stabilizing key signaling and structural proteins, HSC70 allows cells to adapt and recover from damage. Its protective function underscores why Hsp70 family proteins are considered central to stress tolerance mechanisms.
In disease contexts, dysregulation of Heat shock cognate protein 70 has been associated with cancer, infection, and neurodegeneration. Research using Hsp70 antibody has revealed that many tumor cells exploit HSC70 to maintain folding capacity under high metabolic stress, supporting uncontrolled growth. Pathogens, including viruses, hijack HSC70 to aid in replication and assembly. Conversely, in neurodegenerative disorders such as Alzheimer disease, Parkinson disease, and Huntington disease, insufficient chaperone activity allows toxic protein aggregates to accumulate. These findings make HSC70 both a biomarker and a potential therapeutic target.
Hsp70 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression and post translational modifications, immunohistochemistry reveals tissue distribution, and immunofluorescence demonstrates cytoplasmic and vesicular localization. These approaches make Hsp70 antibody indispensable for molecular chaperone research.
By providing validated Hsp70 antibody reagents, NSJ Bioreagents supports studies into proteostasis, autophagy, and disease. Detection of Heat shock cognate protein 70 allows researchers to explore how chaperones regulate folding, trafficking, and degradation across diverse biological systems.
Optimal dilution of the Hsp70 antibody should be determined by the researcher.
A synthesized peptide derived from human Hsp70 was used as the immunogen for the Hsp70 antibody.
Store the Hsp70 antibody at -20oC.
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