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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Fibrinogen beta chain Antibody / FGB (R32603)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32603 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P02675 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells Immunofluorescence : 5ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This Fibrinogen beta chain antibody is available for research use only. |
|
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The fibrinogen beta chain is one of three subunits that make up fibrinogen, a soluble plasma glycoprotein essential for blood clot formation. Synthesized in the liver, fibrinogen circulates in the bloodstream until activated by thrombin during the coagulation cascade. Thrombin cleaves fibrinogen to form fibrin, which then polymerizes to create a stable clot. Researchers frequently use a Fibrinogen beta chain antibody to study hemostasis, thrombosis, and coagulation biology.
The beta chain, encoded by the FGB gene, plays a crucial role in fibrinogen assembly, stability, and interactions with platelets and other clotting factors. Mutations in the FGB gene are associated with congenital fibrinogen disorders, such as afibrinogenemia and dysfibrinogenemia, which can result in bleeding or thrombotic complications. Employing a Fibrinogen beta chain antibody allows scientists to evaluate protein levels and structural integrity in both normal and pathological conditions.
In addition to its central role in coagulation, fibrinogen and its beta chain contribute to processes such as wound healing, inflammation, and tissue repair. Elevated fibrinogen levels are also recognized as a risk factor for cardiovascular disease and stroke, making the protein a valuable biomarker in clinical and translational research. Using a Fibrinogen beta chain antibody provides researchers with a reliable tool to study its involvement in vascular biology and inflammatory disorders.
NSJ Bioreagents offers a high-quality Fibrinogen beta chain antibody validated for applications including western blot, ELISA, and immunohistochemistry. Choosing a Fibrinogen beta chain antibody from NSJ Bioreagents ensures reproducible and accurate detection in studies of coagulation, cardiovascular disease, and inflammatory processes
Optimal dilution of the Fibrinogen beta chain antibody should be determined by the researcher.
Amino acids 193-225 (TNLRVLRSILENLRSKIQKLESDVSAQMEYCRT-human) were used as the immunogen for the Fibrinogen beta chain antibody.
After reconstitution, the Fibrinogen beta chain antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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