- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Decorin antibody detects decorin, a small leucine-rich proteoglycan encoded by the DCN gene. Decorin is a secreted component of the extracellular matrix, where it binds collagen and regulates tissue structure, growth factor signaling, and fibrotic remodeling. Because decorin influences both normal connective tissue organization and disease processes such as cancer and fibrosis, Decorin antibody is widely used in cell biology, oncology, and tissue pathology research.
Decorin consists of a core protein containing leucine-rich repeats with a single glycosaminoglycan chain attached. Its interaction with type I collagen controls fibril diameter and spacing, ensuring mechanical stability of skin, tendon, and cornea. Beyond structural support, decorin modulates signaling molecules including transforming growth factor beta, epidermal growth factor receptor ligands, and insulin-like growth factors. These interactions position decorin as both a structural organizer and a signaling regulator within the extracellular environment.
The Decorin antibody clone DCN/3523 provides reliable and specific recognition of decorin. Clone DCN/3523 has been employed in peer-reviewed studies investigating extracellular matrix biology, fibrotic progression, and tumor microenvironment remodeling. Its consistent performance makes it suitable for immunohistochemistry, immunoblotting, and biochemical assays requiring detection of decorin in tissues and cell culture systems.
Research using clone DCN/3523 has shown how decorin antagonizes pro-fibrotic pathways by sequestering TGF-beta, reducing excessive matrix deposition. In oncology, decorin has been identified as a tumor suppressor, limiting tumor progression by interfering with receptor tyrosine kinase activity. Its absence or reduced expression correlates with aggressive disease in multiple cancers. Beyond pathology, decorin is essential in ocular biology, where it contributes to corneal transparency, and in musculoskeletal tissues, where it supports tendon resilience.
NSJ Bioreagents supplies this Decorin antibody to support connective tissue research, fibrosis models, and tumor biology. Alternate terms include DCN antibody, small leucine-rich proteoglycan antibody, dermatan sulfate proteoglycan antibody, extracellular matrix regulator antibody, and collagen fibrillogenesis regulator antibody.
Optimal dilution of the Decorin antibody should be determined by the researcher.
A human recombinant partial protein (amino acids 212-336) was used as the immunogen for the Decorin antibody.
Store the Decorin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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