DDX1 Antibody [clone 2D4] (RQ6286)

Description

DDX1 (DEAD box protein 1) is an ATP-dependent RNA helicase belonging to the DEAD-box family, which is defined by the conserved Asp-Glu-Ala-Asp sequence motif. These helicases are central to RNA biology, driving structural rearrangements in RNA and ribonucleoprotein complexes. DDX1 participates in diverse processes including RNA splicing, mRNA transport, ribosome assembly, and transcriptional regulation. Researchers often use a DDX1 antibody to explore these broad contributions to RNA metabolism.

Beyond its RNA-related roles, DDX1 has been connected to genome maintenance. It is recruited to sites of DNA double-strand breaks, where it interacts with repair proteins and promotes genomic stability. This dual role in RNA and DNA regulation underscores its importance in preserving cell integrity. Using a DDX1 antibody helps clarify how the protein integrates RNA processing with DNA repair pathways.

DDX1 expression has been reported in multiple cancer types, where it supports rapid growth and metabolic adaptation of tumor cells. Additionally, it has been shown to facilitate replication of several RNA viruses by binding viral RNA, making it a relevant target in host-pathogen studies. Employing a DDX1 antibody enables the detection and characterization of its functions in both oncogenic and infectious contexts.

NSJ Bioreagents offers a validated DDX1 antibody designed for reliable performance in applications such as western blot, immunohistochemistry, and immunoprecipitation. A high-quality DDX1 antibody ensures reproducible results in studies focused on RNA helicase biology, cancer, and virology.

Application Notes

Optimal dilution of the DDX1 antibody should be determined by the researcher.

Immunogen

A human recombinant partial protein (amino acids K562-F740) was used as the immunogen for the DDX1 antibody.

Storage

After reconstitution, the DDX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.