- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CREB5 antibody detects cAMP response element-binding protein 5, a transcription factor encoded by the CREB5 gene. CREB5 is a member of the CREB/ATF family of transcription factors and regulates gene expression in response to cAMP and stress signals. Because CREB5 participates in development, stress adaptation, and cancer progression, CREB5 antibody is widely used in oncology, molecular biology, and transcriptional regulation research.
CREB5 binds to cAMP response elements within promoters to regulate transcription of target genes. Its activity is modulated by phosphorylation through signaling pathways including PKA and MAPK. By integrating extracellular stimuli with nuclear transcriptional responses, CREB5 influences cell survival, proliferation, and differentiation. In cancer biology, aberrant CREB5 activity has been linked to metastasis and resistance to therapy.
The CREB5 antibody clone PCRP-CREB5-1G8 provides specific and reproducible detection of this transcription factor. Clone PCRP-CREB5-1G8 has been cited in peer-reviewed studies investigating gene regulation, tumor biology, and developmental processes. Its applications include immunoblotting, immunohistochemistry, and chromatin-related assays, where precise recognition of transcription factors is required.
Research using clone PCRP-CREB5-1G8 has clarified how CREB5 regulates stress-responsive transcription in neuronal and epithelial cells. In oncology, this antibody has been used to explore CREB5 overexpression in aggressive cancers, where it promotes invasion and survival signaling. Beyond cancer, CREB5 detection has supported studies of metabolic regulation, neural development, and endocrine signaling, highlighting its broad biological relevance.
NSJ Bioreagents supplies this CREB5 antibody to support oncology, developmental biology, and transcriptional research. Alternate designations include cAMP response element-binding protein 5 antibody, transcription factor CREB5 antibody, CREB/ATF family member antibody, stress response transcription factor antibody, and gene expression regulator antibody.
Optimal dilution of the CREB5 antibody should be determined by the researcher.
Recombinant full-length human CREB5 protein was used as the immunogen for the CREB5 antibody.
Aliquot the CREB5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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