- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CK5 antibody detects cytokeratin 5, a type II intermediate filament protein encoded by the KRT5 gene. Cytokeratin 5 is expressed in basal epithelial cells, where it pairs with keratin 14 to maintain cytoskeletal integrity and resist mechanical stress. Because of its role as a basal cell marker and frequent use in pathology, CK5 antibody is essential in oncology, dermatology, and epithelial biology.
Cytokeratin 5 contributes to the structural framework of stratified epithelia, including skin, lung, and the cervix. Its expression defines basal epithelial layers and supports cellular resilience against environmental insults. Dysregulation of CK5 expression has been implicated in squamous cell carcinoma, basal-like breast cancer, and chronic inflammatory skin diseases. Detection of CK5 provides a reliable means of characterizing epithelial differentiation and tumor subtype.
The CK5 antibody clone KRT5/6466 provides specific and reproducible recognition. Clone KRT5/6466 has been cited in peer-reviewed studies of carcinoma classification, skin pathology, and epithelial differentiation. It is suitable for immunohistochemistry, Western blotting, and immunofluorescence, where accurate detection of CK5 is critical.
Research using clone KRT5/6466 has demonstrated how CK5 expression distinguishes squamous cell carcinoma from adenocarcinoma, particularly in lung and breast cancers. In dermatology, CK5 detection highlights basal keratinocytes in normal skin and in hyperproliferative conditions such as psoriasis. Beyond oncology and dermatology, this antibody has supported developmental studies examining how basal keratins regulate epithelial regeneration and stratification.
NSJ Bioreagents provides this CK5 antibody to support oncology, dermatology, and epithelial research. Alternate designations include KRT5 antibody, cytokeratin type II cytoskeletal 5 antibody, basal keratinocyte marker antibody, stratified epithelium intermediate filament antibody, and squamous carcinoma marker antibody.
Optimal dilution of the CK5 antibody should be determined by the researcher.
A portion of amino acids 316-590 was used as the immunogen for the CK5 antibody.
Aliquot the CK5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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