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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ceruloplasmin Antibody / CP [clone 31C62] (FY12531)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12531 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 439 |
| Availability | 2-3 weeks |
| Species Reactivity | Human, Rat |
| Format | Liquid |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 31C62 |
| Purity | Affinity-chromatography |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| UniProt | P00450 |
| Applications | Western Blot : 1:500-1:2000 |
| Limitations | This Ceruloplasmin antibody is available for research use only. |
|
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Ceruloplasmin antibody detects ceruloplasmin, a copper binding glycoprotein encoded by the CP gene. Ceruloplasmin is synthesized in the liver and secreted into the plasma, where it carries more than 95 percent of circulating copper. It functions as a ferroxidase enzyme that oxidizes Fe2 plus to Fe3 plus, enabling iron binding to transferrin. Through this activity, ceruloplasmin maintains systemic iron and copper balance, supports antioxidant defense, and regulates oxidative stress.
Ceruloplasmin antibody is widely applied in studies of metabolism, neurodegeneration, and inflammatory disease. Abnormal ceruloplasmin levels are associated with Wilson disease, aceruloplasminemia, and other disorders of copper metabolism. In addition, altered expression occurs in Parkinson disease and Alzheimer disease, where oxidative stress contributes to pathogenesis. By detecting ceruloplasmin, researchers can evaluate copper homeostasis and its links to neurological disorders.
In western blot assays, ceruloplasmin antibody detects protein bands of the expected size in serum and liver extracts. Immunohistochemistry highlights hepatocyte production and distribution in tissues, while ELISA applications support quantification of ceruloplasmin levels in plasma. These methods make ceruloplasmin antibody useful for both clinical and experimental research.
Ceruloplasmin also acts as an acute phase reactant, with levels rising during inflammation and infection. Elevated ceruloplasmin is observed in autoimmune disease, cardiovascular disease, and cancer. By applying ceruloplasmin antibody, scientists can study how changes in CP expression reflect inflammation and metabolic stress.
Ceruloplasmin antibody from NSJ Bioreagents offers reliable specificity for studying copper and iron metabolism, oxidative stress, and disease mechanisms. Its performance across multiple assays makes it a valuable resource for metabolic and neurological research.
Optimal dilution of the Ceruloplasmin antibody should be determined by the researcher.
A synthesized peptide derived from human Ceruloplasmin was used as the immunogen for the Ceruloplasmin antibody.
Store the Ceruloplasmin antibody at -20oC.
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