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Home >> Antibodies >> CENP-R Antibody / Centromere protein R / ITGB3BP

CENP-R Antibody / Centromere protein R / ITGB3BP (RQ8767)

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  Catalog No Formulation Size Price (USD)  
Image RQ8767 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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Immunofluorescent staining of FFPE human A549 cells with CENP-R antibody (red) and Beta Tubulin mAb (green). HIER: steam section in pH6 citrate buffer for 20 min.
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Immunofluorescent staining of FFPE human A549 cells with CENP-R antibody (red) and Beta Tubulin mAb (green). HIER: steam section in pH6 citrate buffer for 20 min.
Western blot testing of human 1) 293T, 2) K562, 3) A431 and 4) HeLa cell lysate with CENP-R antibody. Predicted molecular weight ~20 kDa.
Availability 1-3 days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity chromatography
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q13352
Localization Nuclear, cytoplasmic
Applications Western Blot : 1-2ug/ml
Immunofluorescence : 5ug/ml
ELISA : 0.1-0.5ug/ml
Limitations This CENP-R antibody is available for research use only.
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Description

Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the CENP-R antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (amino acids M1-N177) was used as the immunogen for the CENP-R antibody.

Storage

After reconstitution, the CENP-R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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