- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD39 Antibody [clone rCD39/8682] (V4117)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4117-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V4117-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V4117SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rCD39/8682 |
| Purity | Protein A/G affinity |
| UniProt | P49961 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD39 antibody is available for research use only. |
|
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CD39 antibody is an essential reagent for studying vascular biology, thrombosis, and endothelial regulation. The encoded protein, CD39, is an ectoenzyme responsible for hydrolyzing extracellular nucleotides, thereby modulating vascular tone and platelet activation. By converting ATP and ADP into AMP, CD39 serves as a natural inhibitor of thrombosis and maintains vascular integrity.
In endothelial cells, CD39 is highly expressed and functions as a protective factor against uncontrolled clot formation. Its activity prevents platelet aggregation by eliminating platelet-stimulating nucleotides from the circulation. This protective role extends to microcirculatory function, where CD39 maintains fluid flow and prevents ischemic damage. Reduced expression or impaired activity of CD39 has been associated with vascular diseases including atherosclerosis, myocardial infarction, and stroke.
Beyond vascular protection, CD39 also contributes to inflammatory regulation. In conditions such as sepsis or ischemia-reperfusion injury, CD39 expression is rapidly upregulated to limit tissue damage caused by excessive ATP signaling. These functions demonstrate how CD39 integrates vascular health with immune control, linking purinergic metabolism to tissue repair.
At the structural level, CD39 contains two transmembrane domains and large extracellular loops with apyrase motifs essential for nucleotide hydrolysis. Its function requires divalent cations and is sensitive to substrate concentration, allowing fine-tuned control of vascular responses. By coupling with CD73, CD39 provides a complete enzymatic pathway for adenosine production, a critical mediator of vasodilation and tissue protection.
The CD39 antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to measure protein expression in endothelial cells and vascular tissues. These applications are vital for studies of cardiovascular disease, clotting disorders, and vascular inflammation. For investigators researching blood vessel biology, thrombosis, or therapeutic targets in cardiovascular health, the CD39 antibody offers a robust and specific detection tool. NSJ Bioreagents provides validated antibodies that deliver reproducibility and precision in advanced vascular research.
Optimal dilution of the CD39 antibody should be determined by the researcher.
Recombinant full-length human CD39 protein was used as the immunogen for the CD39 antibody.
Aliquot the CD39 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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