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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD39 Antibody [clone CD39/6860] (V4115)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4115-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V4115-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V4115SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | CD39/6860 |
| Purity | Protein A/G affinity |
| UniProt | P49961 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This CD39 antibody is available for research use only. |
|
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CD39 antibody is a reliable tool for studying immune suppression, inflammation, and tumor immunology. The encoded protein, also known as ectonucleoside triphosphate diphosphohydrolase 1, is an ectoenzyme that regulates extracellular nucleotide metabolism. By hydrolyzing ATP and ADP into AMP, CD39 limits inflammatory danger signals and generates substrates for adenosine production. This dual activity positions CD39 as a master regulator of purinergic signaling in the immune system.
CD39 is broadly expressed on endothelial cells, regulatory T cells, B cells, dendritic cells, and some myeloid subsets. On T regulatory cells, CD39 combines with CD73 to generate adenosine, which dampens effector T cell responses and promotes tolerance. In the tumor microenvironment, CD39 contributes to an immunosuppressive niche, helping cancer cells evade immune attack. High expression is therefore associated with poor prognosis in many cancers, including colorectal, breast, and lung carcinoma.
In addition to its role in cancer, CD39 is relevant in autoimmune and inflammatory conditions. Reduced CD39 activity correlates with hyperactive immunity in diseases such as multiple sclerosis and inflammatory bowel disease. Conversely, overexpression of CD39 has been implicated in chronic infections, where immune responses are suppressed. These findings highlight the importance of CD39 in balancing protective immunity with tolerance.
At the molecular level, CD39 belongs to the ecto-ATP diphosphohydrolase family and contains conserved apyrase motifs essential for catalytic activity. Its enzymatic function depends on divalent cations such as magnesium or calcium. By controlling the levels of extracellular ATP, a potent proinflammatory molecule, CD39 prevents excessive immune activation while enabling adenosine generation. This mechanism makes it a key checkpoint in immune regulation.
The CD39 antibody is widely applied in flow cytometry, immunohistochemistry, immunofluorescence, and western blotting. These methods allow scientists to evaluate cell type-specific expression, monitor changes in immune states, and assess therapeutic interventions targeting the adenosine pathway. For researchers focused on immuno-oncology, autoimmunity, or transplantation, the CD39 antibody provides a dependable detection tool. NSJ Bioreagents supplies validated antibodies designed for reproducibility and accuracy in advanced research.
Optimal dilution of the CD39 antibody should be determined by the researcher.
Recombinant full-length human CD39 protein was used as the immunogen for the CD39 antibody.
Aliquot the CD39 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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