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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD36 Antibody / Platelet glycoprotein 4 (FY13262)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13262 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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CD36 antibody detects Platelet glycoprotein 4, a multifunctional membrane receptor involved in lipid metabolism, angiogenesis, inflammation, and immune regulation. The UniProt recommended name is Platelet glycoprotein 4 (CD36). This scavenger receptor binds a wide range of ligands, including oxidized low-density lipoproteins (oxLDL), long-chain fatty acids, thrombospondin, and collagen, linking metabolic and inflammatory signaling pathways.
Functionally, CD36 antibody identifies a 472-amino-acid glycoprotein expressed on the plasma membrane of platelets, macrophages, adipocytes, and endothelial cells. CD36 mediates fatty acid uptake and translocation across membranes, contributing to energy homeostasis and lipid storage. It also functions as a pattern recognition receptor in innate immunity, detecting oxidized lipids and apoptotic cells. Engagement of CD36 triggers signaling cascades involving Src-family kinases, MAPKs, and NF-kB, influencing inflammation, oxidative stress, and phagocytosis.
The CD36 gene is located on chromosome 7q21.11 and is expressed in a broad range of tissues, including heart, skeletal muscle, liver, and immune cells. Expression is regulated by transcription factors such as PPARgamma and LXR, which respond to lipid availability and metabolic stress. CD36 plays a central role in coordinating cellular responses to lipid signals and oxidative modification.
Pathologically, CD36 dysregulation contributes to atherosclerosis, insulin resistance, and metabolic syndrome. Overexpression in macrophages promotes foam cell formation and plaque development, while impaired expression leads to altered lipid uptake and cardiac dysfunction. In cancer, CD36 enhances metastatic potential by supporting lipid utilization in tumor cells. Research using CD36 antibody supports studies in lipid biology, cardiovascular disease, and metabolic signaling.
CD36 antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cell surface receptors. NSJ Bioreagents provides CD36 antibody reagents optimized for research in lipid transport, oxidative stress, and immune modulation.
Structurally, Platelet glycoprotein 4 consists of two transmembrane domains, a large extracellular glycosylated loop, and short cytoplasmic tails that mediate signal transduction. The receptor interacts with caveolin and other membrane components to form lipid raft-associated complexes. This antibody enables investigation of CD36's function in lipid metabolism, inflammation, and vascular biology.
Optimal dilution of the CD36 antibody should be determined by the researcher.
E.coli-derived human CD36 recombinant protein (Position: K233-N439) was used as the immunogen for the CD36 antibody.
After reconstitution, the CD36 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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