CD3 zeta Antibody / CD247 (R34549)

Description

CD3 zeta (CD247) is a signaling molecule within the T cell receptor (TCR)–CD3 complex, functioning as a key amplifier of antigen-driven activation. Its cytoplasmic domain contains multiple immunoreceptor tyrosine-based activation motifs (ITAMs) that recruit and activate downstream kinases, facilitating the transmission of activation signals to the nucleus.

Beyond its role in initiating T cell responses, CD3 zeta influences TCR surface expression, immune synapse stability, and the development of effector and memory T cell populations. Dysregulation of CD3 zeta has been implicated in immune exhaustion, certain leukemias, and autoimmune disorders, making it an important focus for translational and basic immunology research.

Using a high-quality CD3 zeta antibody enables sensitive and specific detection in applications such as western blot, flow cytometry, and immunohistochemistry. A CD3 zeta antibody from NSJ Bioreagents provides reliable performance for examining TCR signal strength, tracking T cell activation states, and exploring disease-associated immune alterations. Selecting the appropriate CD3 zeta antibody is essential for generating robust and reproducible data.

Application Notes

Optimal dilution of the CD3 zeta antibody should be determined by the researcher.

Immunogen

Amino acids KNPQEGLYNELQKD were used as the immunogen for this CD3 zeta antibody.

Storage

Aliquot and store the CD3 zeta antibody at -20oC.