- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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CD27 antibody detects CD27, a type I transmembrane glycoprotein encoded by the TNFRSF7 gene. CD27 is a member of the tumor necrosis factor receptor superfamily and is expressed primarily on T cells, B cells, and natural killer cells. Interaction with its ligand CD70 provides a costimulatory signal that enhances survival, differentiation, and effector function. Because of its central role in lymphocyte biology, CD27 antibody is widely used in immunology, oncology, and vaccine research.
Structurally, CD27 consists of an extracellular cysteine-rich domain for ligand binding, a transmembrane region, and a cytoplasmic tail containing TRAF-binding motifs. Engagement of CD27 by CD70 activates NF-κB and MAPK pathways, promoting clonal expansion of T and B cells and supporting memory cell development. Its expression on subsets of T cells, particularly memory populations, makes it a marker for immune monitoring.
The CD27 antibody clone LPFS2/1611 provides reliable and specific detection. Clone LPFS2/1611 has been applied in peer-reviewed publications addressing T-cell costimulation, immune memory, and tumor immunology. Its reproducibility supports use in flow cytometry, immunohistochemistry, and cell culture experiments, where characterization of lymphocyte subsets and signaling pathways is essential.
Research using clone LPFS2/1611 has shown how CD27-CD70 interactions are critical for long-term immunity, including responses to viral infection and vaccination. In oncology, CD27 expression has been studied in tumor-infiltrating lymphocytes, where it reflects activation states and potential responsiveness to immunotherapy. The antibody has also contributed to studies of immune dysregulation in autoimmunity, where aberrant signaling through CD27 pathways alters lymphocyte balance and function.
NSJ Bioreagents supplies this CD27 antibody to support research in immunology, oncology, and translational medicine. Alternate names include TNFRSF7 antibody, T-cell activation antigen CD27 antibody, lymphocyte differentiation antigen antibody, tumor necrosis factor receptor superfamily member 7 antibody, and memory T-cell marker antibody.
Optimal dilution of the CD27 antibody should be determined by the researcher.
A recombinant full-length human CD27 protein was used as the immunogen for this CD27 antibody.
Store the CD27 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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