CBS Antibody / Cystathionine Beta Synthase (RQ8923)

Description

CBS (Cystathionine Beta Synthase) is a pyridoxal-5'-phosphate-dependent enzyme that plays a central role in the transsulfuration pathway. It catalyzes the condensation of serine and homocysteine to form cystathionine, an essential step in the synthesis of cysteine. This pathway is critical for maintaining sulfur amino acid metabolism, redox balance, and cellular homeostasis. A CBS antibody is commonly used in research focused on amino acid metabolism and associated disorders.

In addition to its role in cysteine biosynthesis, CBS activity contributes to the regulation of homocysteine levels. Elevated homocysteine is a known risk factor for cardiovascular disease, stroke, and neurodegeneration. Mutations in the CBS gene are responsible for homocystinuria, a metabolic disorder characterized by abnormal accumulation of homocysteine, highlighting the enzyme’s clinical significance. Researchers employ a CBS antibody to study enzyme expression and function in metabolic pathways and disease models.

CBS is also involved in producing hydrogen sulfide (H2S), a gaseous signaling molecule with important roles in vascular function, neuromodulation, and cytoprotection. Dysregulated H2S production has been associated with cancer, hypertension, and neurological disease. Investigating CBS with a CBS antibody allows researchers to better understand its enzymatic versatility and its impact on multiple signaling networks.

NSJ Bioreagents offers a high-quality CBS antibody validated for applications such as western blot, immunohistochemistry, and immunoprecipitation. Selecting a CBS antibody from NSJ Bioreagents ensures reliable detection and reproducible results in studies of sulfur metabolism, homocysteine regulation, and disease biology.

Application Notes

Optimal dilution of the CBS antibody should be determined by the researcher.

Immunogen

A human recombinant partial protein (amino acids K102-E342) was used as the immunogen for the CBS antibody.

Storage

After reconstitution, the CBS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.